Vitamin D

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Vitamin D PPT Free Download. Get paper presentation and seminar topics about What is Vitamin D, Physiology, function of vitamin d, Calcitriol and CNS function on Vitamin D PPT format.

What is Vitamin D?
 Vitamin D receptors found in gut, bone, brain, breast, prostate, lymphocytes, placenta, and other tissues
 Routine screening is appropriate
 Safe up to 4000iu/d without monitoring
 Safe up to 10,000iu/d with monitoring
 Supplementation helpful in: DM, metabolic syndrome, CAD, depression, autoimmune diseases, various cancers, HTN, osteoporosis, osteoarthritis, pain, MS, epilepsy, elderly fall prevention, PCOS, pregnancy & lactation, periodontal disease, URI and influenza, and decreasing all-cause mortality.

Physiology
 Vitamin D3 (Cholecalciferol)

  • Produced in skin with direct sunlight, cod liver oil
  • Preferred form of supplementation

 Vitamin D2 (Ergocalciferol)

  • Made by irradiating fungi
  • Less effective as precursor to 1,25(OH)2-Vit D

 Hepatic conversion of Vit D3 to 25-OH-Vit D (calcidiol)
 Conversion of 25-OH-Vit D to 1,25(OH)2-Vit D (calcitriol)

  • Previously thought exclusively renal
  • Requires two factors
    • 25OH-VitD3-1-alpha-OHase
    • Vitamin D Receptor (VDR)

 

 

Autocrine Metabolism
 Vitamin D functions as a steroid hormone
 Cells containing 25OH-VitD3-1-alpha-OHase

  • Breast, prostate, lung, skin, lymph nodes, colon, pancreas, adrenal medulla, brain, placenta
    • Holllick MF. Am J Clin Nutr. 2004. 79(3):362.
    • Zehnder et al. J Clin Endocrin Metab. 2001;86(2)

 Cells containing Nuclear VDR

  • Pancreatic islet cells, monocytes, transformed B cells, activated T cells, neurons, prostate, ovaries, pituitary, aortic endothelium, placenta, skeletal muscle cells.
    • Zittermann A. Br J Nutr. 2003;89(5):552.
    • Bischoff HA, et al. Histochem J 2001;33:19.

 

Calcitriol and CNS function
 Vit D Modulates neurotransmitter and neurological function
 Anticonvulsant and antidepressant effect
 Landsdowne et al. Psychopharmacology. 1998;135.
 Christiansen et al. Br Med J. 1974;2(913): 258.

Vitamin D Content:
1. What is Vitamin D?
2. Physiology
3. Autocrine Metabolism
4. Calcitriol and CNS function
5. Calcitriol and Cancer
6. Parathyroid Hormone
7. Calcium Absorption
8. Heart Disease
9. And more.

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